- Ron's Pizza Palace
- Roslonski Optical
- Ross Bianco Architects
- Rothrock's Kung Fu & Tai Chi
- Rudberg Law Offices
- Ruggers Pub
- Rumshakers
- Rynn's Luggage
- Rynn's Luggage Inc
- Rynns Luggage
- S & S Candy & Cigar Co
- S M Swamy Inc
- Sally Beauty Supply
- Salvation Army
- Salvation Army
- Sandra Solomon Assoc Inc
- Sanyo Chemical Resins
- Sarah Street Townhouses
- Satira Associates
- Savikas & Co
- Schafer's Sewing
- Schwartz Market
- Scientology Pittsburgh
